The importance of honey for medicinal purposes is well documented in some of the world’s oldest literature. Honey is well known and studied for its antimicrobial properties. The medicinal properties in honey originate from the floral source used by bees. Manuka honey is a dark monofloral honey rich in phenolic content, and currently it is gaining much attention for its antimicrobial activity. Researchers have found that honey is effective against a wide range of pathogens. The antibacterial potency of Manuka honey was found to be related to the Unique Manuka Factor (UMF) rating, which is correlated with the methylglyoxal and total phenols content. It is reported that different types of Manuka honey have differing effects and Gram-negative bacteria are more resistant than Gram-positive bacteria. Bacterial resistance to honey as antimicrobial agent has yet to be identified, possibly due to the presence of a complex mixture of methylglyoxal and other components. Honey is also reported to alter a bacterium’s shape and size through septal ring alteration, which affects cell morphology and growth. Research has shown that Manuka honey of different UMF values has medicinal properties of interest and it can be beneficial when used as a combination treatment with other antimicrobial agents.
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Manuka Tree: What To Know About The Manuka tea tree’s distinctive traits and its symbiotic relationship with bees in New Zealand create the unique, nutrient-packed nectar that makes Manuka honey so prized across the globe.
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A new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center found that Manuka honey could potentially be an alternative, natural option for breast cancer prevention and treatment— particularly for estrogen receptor (ER)-positive breast cancer, the most common subtype of breast cancer that accounts for about 70–80% of all breast cancer cases.
In preclinical experiments, researchers found:
Manuka honey significantly reduced tumor growth in mice with ER-positive breast cancer cells by 84% without affecting normal breast cells or causing major side effects.
Higher concentrations of Manuka honey led to a greater reduction in cancer cell growth.
Manuka honey reduced levels of signaling pathways that are upregulated in cancer such as AMPK/AKT/mTOR and STAT3, which are involved in tumor cell growth and survival.
Manuka honey reduced the proliferation of cancer cells but did not affect the growth of normal human mammary epithelial cells, indicating it might target cancer cells specifically.
Manuka honey induced apoptosis or cell death of breast cancer cells.
The Manuka honey enhances the effectiveness of existing treatments such as tamoxifen, a commonly used antiestrogen drug in ER-positive breast cancer therapy, when used to together.
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Contact us for more info:
Todd D. Sonoga +1 949-705-8021
Brian Vollmer +1 949-987-6134
General Inquiries manukabroker@gmail.com
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